- Hyung Jun Kim
- Yonsei University College of Dentistry
- Value of FDG-PET/MRI in peripheral nerve injury models
Introduction: The aim of this study was to evaluate the diagnostic efficacy of 18F-FDG PET/MRI in peripheral neuropathic pain models using injured rat sciatic nerves.
Method and materials: Three experiments were performed for this study. The first experiment was performed to evaluate 18F-FDG PET/MRI as a diagnostic tool in two different peripheral neuropathic pain models. Thirteen male SD rats (7weeks, 200-250g) were used in this experiment. One rat was left intact, with no surgery performed (normal), and the other twelve rats, with operation on left sciatic nerves, were evenly divided into three groups: sham surgery group (control group), crushing injury group and chronic constriction injury (CCI) group (experimental group). The second experiment was performed to evaluate of peripheral nerve injury according to the severity of damage using 18F-FDG PET/MRI. Eighteen rats were used and evenly divided into three groups in this experiment: 30 seconds crushing injury group, 2 minutes crushing injury group and 5 minutes crushing injury group. In the first and second experiments, the degree of nerve damage was measured at 3 weeks postoperatively using following assessment methods: paw withdrawal threshold values (RevWT), maximum standardized uptake values on PET/MRI images (SUVR), and histomorphologic analysis (MAxR). The third experiment was performed to assess the recovery over time after peripheral nerve injuries using different imaging modalities, PET and MRI. Six rats were used in this experiment. Crushing nerve injuries (40N, 5 minutes) were formed in the left sciatic nerves of all rats. The degree of nerve damage was measured at 1, 2, 3, 4 and 5 weeks postoperatively using three assessment methods: RevWT, SUVR and the relative signal intensity values on MR images (MRSIR). The results were quantified and statistically analyzed.
Results: In the first experiment, compared to the control group, the crushing injury group demonstrated significant differences in RevWT (p = 0.000) and SUVR (p = 0.027) and the CCI group demonstrated significant differences in RevWT (p = 0.000), SUVR (p = 0.001) and MAxR (p = 0.048). There were no significant differences between the two experimental groups for all assessments. Correlation analysis demonstrated that RevWT and SUVR were highly correlated (r = -0.710, p = 0.010), and SUVR and MAxR were highly correlated (r = 0.611, p = 0.035). However, there was no significant correlation between RevWT and MAxR (r = -0.567, p = 0.055). In the second experiment, there was no significant differences in RevWT among three groups at 3 weeks postoperatively (p = 0.401, 0.762, 0.811). However, there were significant differences between 30 seconds and 2 minutes groups, and between 30 seconds and 5 minutes groups in SUVR (p = 0.001, 0.001). There was no significant difference between 2 minutes and 5 minutes groups (p = 0.896). In the third experiment, significant gradual recoveries of all rats were observed over time in all methods. From 4 weeks after injury, there was no significant difference with before injury in RevWT and MRSIR (p = 0.5, 0.0627, respectively), but in SUVR, there was still a significant difference with before injury at 5 weeks after injury (p = 0.0007). In the linear regression analysis, the parameters of the three assessment methods significantly decreased over time (p = 0.000, all), and the explanatory power was significant in RevWT, SUVR and MRSIR (adjusted R-squared = 0.89, 0.50, 0.37, respectively).
Conclusion: 18F-FDG PET/MRI may be a valuable imaging modality to enable noninvasive, objective diagnosis of peripheral nerve injury. PET scan is expected to be a more accurate and informative diagnostic imaging modality for peripheral nerve injury than clinical neurosensory test and MRI. MRI fused with PET may help clarify the anatomic location of soft tissue structures, including the peripheral nerves.
Keywords : Peripheral nerve injury, Neuropathic pain, Crushing injury, Positron emission tomography (PET), Magnetic resonance imaging (MRI)
Graduated from Yonsei University College of Dentistry and took one year Internship and three year Residency, and two year Fellowship in Oral and Maxillofacial Surgery at Yonsei University Health System.
Received Doctor of Dental Surgery and Master of Science in Dentistry degrees in Yonsei University and Dr. med. dent. degree in Ludwig-Maximilians University, Munich, Germany.
Visiting Scholar, Oral and Maxillofacial Surgery, Ludwig-Maximilians University, Munich, Germany. (Oct. 1997 – Sep. 1999)
Visiting Professor, Institute of Surgical Experiment, Ludwig-Maximilians University, Munich, Germany. (Feb. 2006 – Jan. 2007)
Visiting Professor, Oral and Maxillofacial Surgery, Tokyo Dental College, Japan. (Jun. 2008)
Visiting Professor, Oral and Maxillofacial Surgery, Technical University of Munich, Germany. (Oct. 2013)
Professor in Oral and Maxillofacial Surgery, Yonsei University College of Dentistry.
Adjunct Professor in Oral Biology, Yonsei University College of Dentistry
President, Korean Association of Oral and Maxillofacial Surgeons
Councilor, Asian Association of Oral and Maxillofacial Surgeons
Research Ambassador, German Academic Exchange Service
Member, Professional Review Committee, Seoul District Court
Member, Professional Review Committee, Health Insurance Review and Assessment Service
Past appointments
Chairman in Oral and Maxillofacial Surgery, Yonsei University College of Dentistry.
Director of Education and Research, Yonsei University Dental Hospital
Director of Institutional Review Board, Yonsei University College of Dentistry
Director of General Affairs, Korean Association of Oral and Maxillofacial Surgeons
Secretary General, Korean Association of Maxillofacial Plastic and Reconstructive Surgery
Director in Information and Communication, Korean Association of Oral and Maxillofacial Surgeons
Director in Information and Communication, Korean Association of Maxillofacial Plastic and Reconstructive Surgery
Director in Management Planning, Korean Academy of Dental Science
Vice-President, Korean Academy of Implant Dentistry
Member, Dental Division of Korean Society of Osteoporosis
Publications
Longitudinal detection of somatic mutations in saliva and plasma for the surveillance of oral squamous cell carcinomas, PLOS ONE, 2021
Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma, SCIENTIFIC REPORTS, 2021
Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma, ORAL DISEASES, 2021
Postoperative Concurrent Chemoradiotherapy Versus Radiotherapy Alone for Advanced Oral Cavity Cancer in the Era of Modern Radiation Techniques, FRONTIERS IN ONCOLOGY, 2021
Handheld Near-Infrared Fluorescence Imaging Device Using Modified Action Cameras for Peri-Operative Guidance of Microvascular Flap Surgery, Journal of Clinical Medicine, 2021
In Vivo Study for Clinical Application of Dental Stem Cell Therapy Incorporated with Dental Titanium Implants, MATERIALS, 2021
Effect of Cyclic Compressive Forces on New Bone Formation during the Distraction Period in Mandibular Distraction Osteogenesis Using a Microactuator-Generated Distractor, PLASTIC AND RECONSTRUCTIVE SURGERY, 2020
Prognostic value of systemic inflammatory markers for oral cancer patients based on the 8th edition of AJCC staging system, SCIENTIFIC REPORTS, 2020
Deep learning for automated detection of cyst and tumors of the jaw in panoramic radiographs, Journal of Clinical Medicine, 2020
Prognostic Implications of Combined Imaging and Histologic Criteria in Squamous Cell Carcinoma with Mandibular Invasion, Journal of Clinical Medicine, 2020
Diagnostic Efficacy of 18F FDG PET/MRI in Peripheral Nerve Injury Models, Neurochemical Research, 2019
Deep learning-based survival prediction of oral cancer patients, Scientific Reports, 2019
Accuracy of modified CAD/CAM generated wafer for orthognathic surgery, PLOS ONE, 2019
70 SCI/SCIE articles and 79 others